Breast Cancer and Gilbert’s Syndrome?

Discoveries of the potential issues for people with Gilbert’s Syndrome are occurring all the time. So little is known, and much is speculated!  I would caution before reading this that this cited article notes that the information they discuss results in their speculation that people with Gilbert’s Syndrome may be more likely to get breast cancer. This is not proven, and is an association only.  However, in the interests of offering new information to people with Gilbert’s Syndrome I present the conclusion below:

Med Hypotheses. 2011 Aug;77(2):162-4. doi: 10.1016/j.mehy.2011.03.047. Epub 2011 Jun 1.

Is Gilbert syndrome a new risk factor for breast cancer?

Source

Medical School, Universidade de São Paulo, Brazil. rafael.astolfi95@gmail.com

Abstract

Patients with Gilbert syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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